GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs943466 | 1 | rs11755593 | chr6:33740325 | C6orf125 | chr6:33662057-33679504:- | 0.11 | 3.54 | 0.000423 | Body mass index |
| BRCA | cis | rs943466 | 1 | rs11755593 | chr6:33740325 | LEMD2 | chr6:33738991-33756906:- | 0.18 | 5.59 | 2.85E-8 | Body mass index |
| BRCA | cis | rs1056667 | 1 | rs11756120 | chr6:26529808 | BTN2A3 | chr6:26422317-26431927:+ | 0.16 | 5.51 | 4.58E-8 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs11756120 | chr6:26529808 | C6orf41 | chr6:26924772-26991752:+ | -0.12 | -3.7 | 0.000227 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs11756120 | chr6:26529808 | ZNF322A | chr6:26634612-26659963:- | -0.1 | -3.5 | 0.000489 | Educational attainment |
| BRCA | cis | rs239198 | 1 | rs11756783 | chr6:101118109 | ASCC3 | chr6:100956609-101329224:- | 0.12 | 4.83 | 1.54E-6 | Menarche (age at onset) |
| BRCA | cis | rs867186 | 1 | rs117573845 | chr20:33651621 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.85 | 0.000126 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs117573845 | chr20:33651621 | PROCR | chr20:33758727-33765164:+ | -0.25 | -4.97 | 7.73E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs16895812 | 1 | rs11758152 | chr6:42496494 | PRPH2 | chr6:42664334-42690358:- | 0.14 | 3.44 | 0.000614 | Obesity-related traits |
| BRCA | cis | rs11758351 | 1 | rs11758351 | chr6:26203910 | HIST1H3E | chr6:26224427-26226589:+ | 0.36 | 7.24 | 8.38E-13 | Renal underexcretion gout;Gout |
| BRCA | cis | rs1577917 | 1 | rs11758849 | chr6:86708262 | SNHG5 | chr6:86386726-86388451:- | -0.5 | -14.57 | 5.29E-44 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs11759855 | chr6:86610841 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -18.42 | 5.21E-66 | Response to antipsychotic treatment |
| BRCA | cis | rs11763147 | 1 | rs11763147 | chr7:65326821 | CCT6P1 | chr7:65216092-65228661:+ | 0.12 | 4.03 | 6.1E-5 | Corneal structure |
| BRCA | cis | rs11763147 | 1 | rs11763147 | chr7:65326821 | CRCP | chr7:65579805-65619551:+ | 0.16 | 4.43 | 1.05E-5 | Corneal structure |
| BRCA | cis | rs11763147 | 1 | rs11763147 | chr7:65326821 | VKORC1L1 | chr7:65338257-65423532:+ | 0.11 | 3.39 | 0.000714 | Corneal structure |